Trenbolone (Trenbolone Acetate)

Trenbolone History and Overview

Trenbolone is a very well-known injectable anabolic steroid, and milligram for milligram it is the most powerful anabolic steroid commercially and conventionally available. It is an anabolic steroid that tends to invoke both intimidation as well as amazement among those who read about it. The truth is that although Trenbolone is not as harsh of an anabolic steroid as many make it out to be, it is by no means a beginner compound and does need to be taken seriously when the use of it is considered. It is typically used by intermediate to advanced level anabolic steroid users, and seldom used by beginners until several cycles of experience has been built up.

Trenbolone is a derivative of Nandrolone (Deca-Durabolin), and alongside Nandrolone, is in the family of anabolic steroids known as 19-nor compounds. This category of 19-nor steroids is named as such due to the fact that these compounds contain a specific alteration at the 19th carbon on the anabolic steroid’s molecular structure. This alteration, which is the removal of the 19th carbon, is not seen in any other anabolic steroid classes. It also contains other alterations in this area that grant it enhanced androgenic strength (its ability to bind at a much greater strength to the androgen receptor)[1][2], as well as a high degree of resistance to metabolic breakdown within the body.

Trenbolone, as a result, expresses five times the androgenic and anabolic strength of Testosterone, with a rating of 500 for each. It also expresses characteristics that grant it the ability to promote weight gain with nearly all of it being muscle mass, and no water retention[3]. Trenbolone has also been found to stimulate endogenous production of the very anabolic hormone IGF-1 (Insulin-like Growth Factor 1) in muscle tissue, adding to its anabolic capabilities[4]. Ultimately, the reason for Trenbolone’s inability to make the user hold onto water and become bloated is due to the fact that its chemical modifications render it unable to aromatize into Estrogen at any dose what so ever[5].

Three major esterified forms of Trenbolone exist: Trenbolone Acetate, Trenbolone Enanthate, and Trenbolone Hexahydrobenzylcarbonate. The most popular and most widely used of the three is the fast-acting acetate variant. Trenbolone’s history generally begins in 1967[6], where it was studied repeatedly in France by Roussel-UCLAF. It was eventually picked up by Hosescht in England and manufactured in its acetate ester format, and sold under the brand name of Finajet. In France, Roussel marketed it as Finaject. Both companies were in reality owned and operated by Roussel AG of Germany. Both brand names of the same product (Trenbolone Acetate) were used on the prescription drug market as human grade medicines before they were discontinued and disapproved for use in humans towards the 1980s. Trenbolone Hexahydrobenzylcarbonate was sold under the brand name Parabolan as well during this time before encountering the same fate as the other two in the 1990s.

Today, Tren remains officially utilized as a veterinary drug, mostly in the application of promoting mass in cattle used to provide food. It remains a peculiar compound of interest to the medical establishment, however, as scientific studies continue to continue with Trenbolone, with scientists discovering new applications for human use and recommending its re-introduction as a human grade medicine. To date, however, Trenbolone is still unapproved for human use by the FDA and all current Trenbolone products are generally underground lab (UGL) products.

trenex 100Trenbolone Side Effects

Trenbolone is often touted as an anabolic steroid that has ‘harsh’ side effects and tends to frighten many individuals who are considering the use of this compound. First and foremost, it should be established that because Tren does not aromatize into Estrogen at any dosage, there is no risk for encountering Estrogenic side effects. The Trenbolone side effects of particular concern are its androgenic side effects, and other side effects that are not usually seen with any other anabolic steroids (such as insomnia, excessive sweating, etc.).

Trenbolone is an extremely powerful androgen and binds very strongly to the androgen receptor[7]. This brings both good news and bad news to the compound, as a very strong androgen also usually means a very strong anabolic (especially in Trenbolone’s case). However, a very strong androgen would be far more likely to generate stronger androgenic side effects. These androgenic side effects include increased oily skin and acne, increased bodily and facial hair growth, increased risk of male pattern baldness (MPB), and an increased risk of benign prostatic hyperplasia (BPH). Alongside these side effects is also the increased propensity for strong androgens to increase aggressive behavior[8], which according to anecdote, can become a concern with users of Trenbolone. How these mental-altering effects are handled will determine whether it becomes a positive or negative issue. These androgenic side effects from Trenbolone cannot be mitigated or controlled with 5-alpha reductase inhibitors such as Proscar, Finasteride, Dutasteride, or Propecia, as these serve to inhibit the reduction of Testosterone into the stronger androgen Dihydrotestosterone (DHT). Trenbolone does not interact with the 5-alpha reductase enzyme at all, and is already a very powerful androgen on its own.

Trenbolone has a tendency to carry with it certain side effects generally unseen with any other compounds. These tend to be increased perspiration (sweating) – especially when sleeping at night – and insomnia (commonly nicknamed ‘trensomnia’). The causes and basis for these peculiar side effects are as of yet unknown, and different hypotheses currently exist to attempt to explain them.

Being that Tren is itself a progestin possessing approximately 60% of the actual strength of progesterone[9], it does carry with it progesterone-related side effects as well. As well, being that Trenbolone’s metabolite (17-beta Trenbolone) is known to bind even stronger to the Progesterone receptor[10], this can become an issue of concern. Trenbolone can also increase Prolactin levels in the body. All of these Progesterone and Prolactin related concerns can manifest themselves as side effects that are very similar to Estrogen – puffy nipples, gynecomastia, bloating, etc. Anti-estrogens and aromatase inhibitors are known for combating these side effects effectively even if they are attenuated through the Progesterone receptor. However, for Prolactin issues, the use of vitamin B6 in order to control Prolactin levels has been demonstrated in studies using 600mg daily[11]. Anti-prolactin drugs such as Cabergoline and Bromocriptine are also very effective at reducing elevated Prolactin levels effectively, and are often the first line of treatment in Prolactin issues[12][13][14].

As an anabolic steroid in general, Trenbolone side effects do include those that are typical of ALL anabolic steroids: HPTA (Hypothalamic Pituitary Testicular Axis) disruption and shutdown, as well as negative cardiovascular effects. Trenbolone in particular, being a very strong androgen and progestin, will induce shutdown of endogenous Testosterone production rather quickly even at very low dosages.

Trenbolone Cycles

Trenbolone cycles are very effective as either fat loss or muscle building mass cycles. As an effective muscle and mass builder, Trenbolone has been shown to bind to the receptors of catabolic hormones[15] and effectively block those hormones from engaging in catabolic signaling to muscle cells. This is of particular importance when it comes to the catabolic hormone Cortisol, which Trenbolone should effectively be able to inhibit[16]. Thus, we can see here how even just through the anti-catabolic effects at the cellular level, Trenbolone should be an excellent compound for cutting cycles during dieting or pre-contest phases where catabolism is an issue. Furthermore, Trenbolone’s effectiveness as a fat loss agent is well documented through its incredible nutrient partitioning effects[17]. We also know that androgen receptors indeed exist in fat cells and play a role in fat loss when activated[18], especially the stronger an androgen binds to this receptor[19][20]. In the arena of mass and bulking, Trenbolone has demonstrated considerable ability to increase nitrogen retention within muscle tissue[18].

For cutting cycles, Tren Ace, for example, is normally stacked with Testosterone Propionate for an 8 – 10 week cycle. Additional compounds with similar effects that assist similar goals (such as fat loss) can also be utilized, such as Anavar (Oxandrolone). For bulking purposes, Trenbolone is normally stacked alongside a solid base of some form of Testosterone (for bulking, usually Testosterone Enanthate), and a similar type of oral compound can be used alongside these, such as Dianabol (Methandrostenolone). An additional injectable, such as Boldenone (Equipoise) can also be utilized during bulking cycles.

trenbolone british dragon pharmaTrenbolone Dosages

Trenbolone is one particular compound whereby massive or large dosages are not necessary by any means. As a compound that is five times the strength of Testosterone itself, there is no need to utilize even ‘moderate’ dosages to achieve desired effects and goals. A little goes a long way when it comes to Trenbolone.

Most beginners would do well with 50mg every other day of Trenbolone Acetate (for a total of 200mg weekly) and is more than enough for staving off muscle loss during a cut. Intermediate Trenbolone dosages venture into the 75 – 100mg every other day range (a total of 300 – 400mg per week), and generally produces stunning changes in the physique. There is seldom a requirement – even for advanced users – to venture beyond this dosage range, as Trenbolone is a very powerful compound that carries with it increased discomfort in the form of side effects in proportion to the dosage used. With that being said, most casual advanced users will not venture beyond 400 – 600mg per week, and only extreme professional and competitive bodybuilders have been known to go higher than this.

How to Buy Trenbolone

On the anabolic steroid black market, Trenbolone is exclusively available only as an underground product. No official pharmaceutical grade products manufactured by FDA-approved pharmaceutical companies exist. For its strength and capabilities, Trenbolone is fairly cheap on the market.

Individuals shopping around to purchase Trenbolone will usually venture into internet website sources that will generally sell Trenbolone Acetate products in the price range of $60 – $100 per 10ml vial. Most sources average around the $75 – $80 mark for a single 10ml vial. Trenbolone Acetate is normally manufactured in concentrations of 75mg/ml or 100mg/ml. Trenbolone Enanthate is usually in the range of $90 – $130 per 10ml vial, and is normally concentrated at 200mg/ml or 250mg/ml.

Trenbolone Information:

TrenboloneTrenbolone (AKA Finaject)
Chemical Name: 17β-Hydroxyestra-4,9,11-trien-3-one
Molecular Weight: 270.37 g/mol
Formula: C18H22O2
Original Manufacturer: Hoechst
Half Life: 3 days (Acetate), 14 days (Hexahydrobenzylcarbonate), 10 days (Enanthate)
Detection Time: 4 – 5 months
Anabolic Rating: 500
Androgenic Rating: 500

Trenbolone References:

  1. Unique steroid congeners for receptor studies. Ojasoo, Raynaud, Cancer Research 38 (1978):4186-98.
  2. Characterisation of the affinity of different anabolics and synthetic hormones to the human androgen receptor, human sex hormone binding globulin and to the bovine progestin receptor. Bauer, Meyer et al. Acta Pathol Microbiol Imunol Scand Suppl 108 (2000):838-46.
  3. Br J Nutr. 1978 Nov;40(3):563-72.
  4. J Cell Physiol. 2004 Nov;201(2):181-9.
  5. Unique steroid congeners for receptor studies. Ojasoo, Raynaud. Cancer Research 38 (1978):4186-98.
  6. Mathieu, Proc. Intern. Symp. Drug Res. 1967, p 134. Chem. Inst. Can., Montreal, Canada.
  7. Toxicol Sci. 2002 Dec;70(2):202-11.15.
  8. Med Sci Sports Exerc. 2003 Jan; 35(1):32-8.
  9. Cancer Res 1978 Nov; 38(11 Pt 2):4186-98.
  10. 2000 Dec;108(12):838-46.
  11. Influence of administration of pyridoxine on circadian rhythm of plasma ACTH, cortisol prolactin and somatotropin in normal subjects. Barletta C, Sellini M, Bartoli A, Bigi C, Buzzetti R, Giovannini C. Boll Soc Ital Biol Sper. 1984 Feb 28;60(2):273-8.
  12. Verhelst J, Abs R, Maiter D, et al. (July 1999). “Cabergoline in the treatment of hyperprolactinemia: a study in 455 patients”. J. Clin. Endocrinol. Metab. 84 (7): 2518–22. doi:10.1210/jc.84.7.2518. PMID 10404830.
  13. Webster J, Piscitelli G, Polli A, Ferrari CI, Ismail I, Scanlon MF (October 1994). “A comparison of cabergoline and bromocriptine in the treatment of hyperprolactinemic amenorrhea. Cabergoline Comparative Study Group”. N. Engl. J. Med. 331 (14): 904–9. doi:10.1056/NEJM199410063311403. PMID 7915824.
  14. Colao A, Di Sarno A, Guerra E, De Leo M, Mentone A, Lombardi G (April 2006). “Drug insight: Cabergoline and bromocriptine in the treatment of hyperprolactinemia in men and women”. Nat Clin Pract Endocrinol Metab 2 (4): 200–10. doi:10.1038/ncpendmet0160. PMID 16932285.
  15. 2001 Jan;109(1):1-8.
  16. J Anim Sci. 1990 Sep;68(9):2682-9.
  17. J Anim Sci. 1992 Nov;70(11):3381-90.
  18. Am J Physiol. 1998 Jun;274(6 Pt 1):C1645-52.
  19. Biochim Biophys Acta. 1995 May 11;1244(1):117-20.
  20. J Appl. Physiol.94 1153-61 2003. J Anim