Pramipexole History and Overview

Pramipexole Dihydrochloride, also known as Prami in bodybuilding circles, is a dopamine agonist that is very similar to the same compounds that work alongside Cabergoline. The primary reason you would use this drug at all is to treat Parkinson’s disease. Pramipexole is very commonly found in the brand names Sifrol, Mirapexin, and Mirapex, there are some generic kinds of these drugs, but for the most part, those three are the primary drugs that are popular. Mirapex is known under the brand Boehringer Ingelheim Pharmaceuticals. Along with treating Parkinson’s, Pramipexole is also prescribed so it can treat people with restless legs syndrome. It’s a drug that has shown a lot of promising signs, especially when treating bipolar disorder, but there are a lot of people that don’t give it this label whatsoever.

Pramipexole Functions and Actions

Pramipexole is a dopamine agonist that works directly with the prolactin hormone. When you increase dopamine levels in your body, prolactin goes down. It is able to do this chemically because it works directly with the dopamine D3 receptor. It’s important to also know that it acts with the D2 receptor and also has somewhat of an affinity for the D3 receptor which is approximately seven times stronger than any other dopamine agonist in existence. Given its availability and its strength, it’s absolutely no surprise that it’s as effective as it is.

Pramipexole has a very profound effect on the D3 receptor, in addition to that, it also has a strong effect on the neurological system. This is why its so effective and is used to treat Parkinson’s disease, and in some cases, it is also used to treat Alzheimer’s. It acts on the D3 receptor, and because of this, it also can improve a man’s sexual interest and willingness to engage in the act itself. Prolactin is very much responsible for why men don’t have a strong libido, and at times, when it gets too elevated, these can lead to severe sexual issues. This is why taking Pramipexole as a man can improve sexual interest and performance, thanks to the elevated levels of dopamine. Pramipexole can also reduce the time in between sex, so the desire to rest or recover is just not as pronounced.

Effects of Pramipexole

The positive thing about Pramipexole medically is specifically tied to the symptoms it addresses in Parkinson’s. For one, it can really boost the mood in someone. It is also used by a lot of performance athletes, however, most of the time just to deal with gynecomastia and improve sexual function that is usually affected by certain kinds of anabolic compounds. Most specifically, any Nandrolone based drugs as well as Tren (although most serious performance athletes would never think about touching Tren) can be dealt with by using Pramipexole or a similar dopamine agonist.

Pramipexole Aspire Pharma

When your prolactin levels go up at a vast rate, in addition to elevated estrogen levels, this can cause gynecomastia, which is the creation of male breast tissue. Even if your estrogen levels aren’t elevated, in men that are sensitive to gynecomastia, prolactin can still cause the formation of this tissue. This is why it’s vital to take a dopamine agonist like Prami or its sister drug Cabergoline; if you don’t do something to reduce the prolactin levels, gynecomastia is still going to be an issue. However, not all men have problems with increased prolactin as a result of steroids, so it is entirely possible that someone could use Deca-Durabolin, which is a Nandrolone-based drug, and not have any prolactin-related issues. That said, this is very dependent on the individual, in addition to the dosage of the substance they’re using in the first place. But having Pramipexole just gives those men one extra layer of control.

Elevated prolactin levels can flat out hurt a man’s sexual performance, most specifically, when it pertains to erections. Nandrolone is very notorious for its ability to inhibit erections causing erectile dysfunction, and many men are wary of trying the drug for this reason alone. Most of the time they will completely avoid it, and this is totally understandable. That said, the reason they are experiencing this problem is related to the prolactin elevation. All it takes is a little bit of Pramipexole, and those unfavourable issues can be avoided, it doesn’t even require a tremendous dose, either. By combining the right hormones and a little bit of Pramipexole, all of these problems can go away and the drug can continue to work without the unfavourable side effects.

As a side benefit, Pramipexole can also increase your serum growth hormone levels. it is not a significant rate, but for some men, the slight increase can be tremendously beneficial for a number of reasons, and lead to much better recovery and deeper sleep. However, the increase is very brief; it typically only lasts a few hours after the initial dosing.

Side Effects of Pramipexole:

When it comes to the side effects, there aren’t too many that are out of control, and most of them are related to the individual genetics of the person taking them. These include nausea, upset stomach, headaches, insomnia, muscle twitches, a general feeling of being weak. Most of the time, any of these issues can be avoided as long as you don’t take too much of the drug. When dosing this dopamine agonist, the doses should always be kept lower if possible just to be on the safe side.

The most common of the above side effects is nausea. This occurs when prolactin is too suppressed and a feeling of uncomfort and illness sets in. This will go with time, but is not a nice feeling at all and should be avoided. Even tiny doses can cause this in some individuals, so Cabergoline should be option #1 for prolactin control.

Pramipexole Administration:

Pramipexole is typically orally in doses ranging from .25mg up to 1.5mg strengths. They are found in oral tablets. The doses for Parkinson’s will be higher than other issues, typically starting at .125mg a few times per day and then eventually increasing to max doses of 1.5 mg 2-3 times per day. If you’re just looking to use the drug to prevent prolactin-related gynecomastia and other symptoms, or if you want to use it for sexual performance, .25-.5mg two times per week is exactly what you ‘ll need. Always start lower and ramp up if needed.

Buy Pramipexole Online:

Always research the laws in your country before buying Pramipexole. Remember, you can get Pramipexole with a prescription (Dostinex), but you can also get it from a myriad of research chemical websites mainly in liquid form, but remember, it’s for research purposes only and not for human consumption.


Overall, Pramipexole is a great option as a dopamine agonist for prolactin control. That said, many find the stomach issues it can present too frustrating to deal with, so rather than dealing with Pramipexole, many would prefer to deal with Cabergoline for prolactin control, but it’s still a powerful option for controlling prolactin levels. Some don’t tolerate Prami well, so Cabergoline is the next best option. Using an aromatase inhibitor (AI) such as, Arimdiex or Aromasin will also help control prolactin via the long feedback mechanism.