Clomid (Clomiphene Citrate)

Overview and History of Clomid

Clomid (Clomiphene Citrate) belongs to a category and class of drugs known as selective Estrogen receptor modulators (SERMs). Selective Estrogen receptor modulators belong to an even broader class of drugs known as anti-estrogens. The other subcategory of drug under the anti-estrogens category is known as aromatase inhibitors (AIs), such as Aromasin (Exemestane) and Arimidex (Anastrozole). AIs and SERMs make up anti-estrogens. Aromatase inhibitors differ greatly from SERMs in their action and how they deal with the issues of estrogen control. The misunderstanding that SERMs, such as Nolvadex and Clomid, serve to lower estrogen levels must first be addressed before delving into any further details.


Clomid 50mg Per Tab

Clomid was developed and approved for use in the early 1970s for the treatment of female infertility (and later on subsequently expanded to treating male infertility as well). Not too long after its release in the United States, its popularity and use spread internationally where, like Nolvadex, its popularity and rate of use is so massive that it is widely and freely available in the majority of countries and regions across the world under an almost infinite number of brand names as well as generic products. Its popularity and cheap cost make it a very easily attainable compound for both medical use as well as off-label use for the anabolic steroid using community.

Clomid, although it is classified as an anti-Estrogen, is actually utilized for the treatment of female infertility resulting from ovulation failure (anovulatory infertility). Although Clomid is a very close relative to Nolvadex with both belonging to the SERM category of drugs, Clomid in reality operates at a much poorer efficiency compared to Nolvadex in regards to its Estrogen antagonistic activity in breast tissue. This is to say that it is a weaker Estrogen blocker in breast tissue, where Nolvadex is much better suited for this task. Instead, Clomid’s prime application in medicine is that of a non-steroidal ovulatory stimulant for women. Because Clomid is a SERM, like Nolvadex, it exhibits mixed Estrogen agonist and antagonist effects in various tissues of the body. Like Nolvadex, Clomid acts as an Estrogen antagonist in the hypothalamus, pituitary gland, ovaries, endometrium, vagina, and cervix. This is to say that in these tissues and areas of the body, Clomid serves to mitigate (inhibit or block) the action of Estrogen.

In males as well as females, its Estrogen antagonistic effect on the hypothalamus will trigger a release of LH (Luteinizing Hormone) and FSH (Follicle Stimulating Hormone). These two hormones in men are the signal hormones that signal the testes to begin or increase its production of Testosterone, and this total process is known as the HPTA (Hypothalamic Pituitary Testicular Axis). In females, this same action occurs, except LH and FSH will trigger the release of eggs from from the ovaries (known as follicular rupture), which would lead to increased chances of contraception. This total process in females is known as the HPOA (Hypothalamic Pituitary Ovarian Axis). Much like Nolvadex, Clomid is what would be considered an Estrogen that acts as a ‘fake’ Estrogen in areas of the body, such as breast tissue (so as to block the effects of ‘real’ Estrogen, while it also works as an actual Estrogen in other areas of the body. This is another manner of describing the agonistic/antagonistic nature of Clomid in regards to Estrogen.

For anabolic steroid using athletes and bodybuilders that are for the most part males, Clomid can serve as an effective anti-Estrogen for the purpose of mitigating one particular unwanted side effect of Estrogen as a result of the use of aromatizable anabolic steroids (such as Testosterone, Dianabol, Boldenone, etc.). This particular unwanted side effect is that of gynecomastia, which refers to the development of breast tissue resulting from excess Estrogen levels in body. Because of Clomid’s Estrogen antagonistic effects on the hypothalamus resulting in the increased production of gonadotropins LH and FSH, Clomid can effectively be utilized to increase endogenous Testosterone production in males. This is especially important for anabolic steroid using individuals that wish to restore proper hormonal function during the weeks following the conclusion of an anabolic steroid cycle, a period known as PCT (Post Cycle Therpay). The traditional protocol for such a use is that of a combination of Nolvadex, Clomid, and HCG (Human Chorionic Gonadotropin) for the duration of several weeks, and although much better more modern protocols have been developed, this long-standing traditional PCT protocol is still effective. The use of Clomid for this purpose will be covered in further detail under the Clomid doses section of this profile.

All of the tripohenylethylene compounds under the SERM family (Nolvadex, Clomid, and Toremifene) also exhibit Estrogen agonistic effects in the liver, meaning the liver is one such area of the body where SERMs such as Clomid (Clomiphene Citrate) will act as an Estrogen rather than block Estrogenic activity there. In studies, this has shown to be a beneficial aspect of SERMs, as Estrogens as well as Estrogen agonists (such as Clomid and Nolvadex) impart a positive effect on cholesterol values through actions in the liver. This is the reason as to why the reduction of Estrogen levels through the use of an aromatase inhibitor (AI) is not always the best decision, as the reduction in Estrogen often results in negatively impacted cholesterol profiles as demonstrated anecdotally as well as in clinical studies.

Chemical Characteristics of Clomid

Clomid (Clomiphene Citrate) is a non-steroidal selective Estrogen receptor modulator (SERM) that possesses both mixed agonistic as well as antagonistic properties in relation to Estrogen in different areas of the body. Clomid belongs to a family of compounds known as triphenylethylene compounds, of which Nolvadex (Tamoxifen Citrate) is also a member of, and a very closely related compound to Clomid.

Properties of Clomid

Clomid’s primary use within the medical field is that of a fertility drug in females but also among males as well.

It has already been established that Clomid, being a SERM, does not reduce circulating Estrogen levels in the body, but instead serves to occupy the receptor sites in breast tissue so that Estrogen itself cannot bind to these receptors due to Clomid’s stronger binding strength to it. In layman’s terms, Clomid essentially acts as a ‘fake’ Estrogen that acts as a placeholder at the receptor sites in breast tissue. As a result, Estrogen cannot activate gene transcription in the cells there in order to formulate gynecomastia, and any existing Estrogen that has already bound to receptor sites will essentially be ‘forced’ out of the receptor sites by Clomid which then occupies the receptor site instead. However, it must be noted that Clomid’s action in this area is far weaker and less efficient than its close relative compound Nolvadex, which serves as a better choice for this purpose.

Although Clomid could indeed be utilized by anabolic steroid using individuals that wish to prevent or eliminate and reverse formulating gynecomastia in its early stages, its more effective and promising role is that of an endogenous Testosterone production stimulating compound. This is the primary purpose and function of Clomid among anabolic steroid using athletes and bodybuilders, and is the primary desired effect in this sense. It must be noted, however, that research has also demonstrated various advantages that Nolvadex does possess over Clomid in this sense as well, which will be further covered in the next section of this profile.

As a SERM, Clomid will not serve to block or reduce any other Estrogenic side effects, however, as it serves only to block Estrogenic activity at the breast tissue area (when major Estrogenic side effects are concerned). Clomid does not (nor do any SERMs) serve to reduce bloating, water retention, rising blood pressure (as a result of water retention), or acne formation – these are all side effects resultant from increasing blood plasma Estrogen levels.

Clomid Side Effects

Clomid is part of the SERM family of medications and it’s a drug which most people tolerate well. However, as with all medications, it does come with the risk of possible side effects. Clomid is anti-estrogenic. It’s utilized as a fertility drug. As well, it’s a medication that many anabolic steroid users rely on in order to lessen or eliminate typical steroid side effects. Clomid itself is not a steroidal drug.

Clomid may cause headaches. Other side effects which are linked with Clomid include nausea and hot flashes. As well, it may cause uterine bleeding in women, although this particular side effect is considered to be rare. In addition, women who use Clomid may notice discomfort in their breasts.

One other possible side effect to be aware of is visual disturbances. Studies show that one and a half percent of people who utilize Clomid experience visual disturbances. For example, their vision may become hazy or blurry while they are taking the medication. People who do experience visual disturbances should stop using Clomid. A physician should be able to prescribe an alternative that serves the same purpose and doesn’t negatively impact vision.

Generally, visual disturbances will cease when a person stops taking Clomid. However, it’s possible that visual disturbances will persist even after usage of this prescription medication is concluded. When Clomid-related problems with vision persist, it’s usually because Clomid was utilized over a longer time frame than average, in a higher dosage than average. People who have blurry or hazy vision while using Clomid should stop taking it and ask their doctors for other SERMs (selective estrogen receptor modulators).

People who take Clomid may also develop acne. In particular, those who use the drug during post-cycle therapy (PCT), may be likely to develop pimples. When used in post-cycle therapy (we’re referring to anabolic steroid post-cycles), it’s not always Clomid that triggers complexion problems. Sometimes, it’s the fact that big amounts of testosterone are being produced naturally. However, Clomid may play some role in the development of acne, which may appear on the shoulders, chest or back, whether the user is involved with anabolic steroids or not.

Clomid Administeration and Uses

Most women who need help due to infertility problems take fifty milligrams of Clomid per day. Clomid is available in pill format so it’s quite simple to take. The dosing schedule for women with fertility problems is one dose a day for five days in a row. If conception doesn’t happen, the dosage may be upped to one hundred milligrams per day. Dosage usually begins five days into a female’s menstrual cycle.

This type of cycle will repeat five or six times until the women becomes pregnant. Usually, treatment with Clomid is stopped after five or six cycles, if the women doesn’t become pregnant. Other options, such as IVF, may be explored, if therapy with Clomid doesn’t have a successful outcome.

Those who use anabolic steroids in order to access estrogenic protection usually take fifty milligrams of the drug, just as women who want to conceive do. Steroids users will take fifty milligrams all though their cycles. If anabolic steroid users don’t get good estrogenic protection from Clomid, they may find that upping their dosages doesn’t change anything. Sometimes, steroid users who don’t get good results from Clomid get better results with another SERM, called Nolvadex. Another option which is popular with steroid users is the aromatase inhibitor, Arimidex.

For post-cycle therapy, steroid users generally begin taking one hundred to one hundred and fifty milligrams of Clomid per day, for one to two weeks. After that time frame, the dosage per day is usually dropped to fifty milligrams per day, or one hundred milligrams if the previous dosage was one hundred and fifty milligrams. The lower dosage is taken for one to two weeks. Overall, this drug should be taken for four to six weeks. Dosage schedules should take that timeline into account.

For post-cycle therapy, a lot of steroid users find that augmenting Clomid therapy with HCG and Nolvadex brings great results. Timing is an important factor when it comes to planning out usage of Clomid for post-cycle therapy. The inclusion of HCG will impact the timing of Clomid usage.

If a cycle concludes with anabolic steroids that have large ester bases, you should start taking Clomid a couple of weeks after your final injection. If your cycle concludes with anabolic steroids with small ester bases, you should start taking Clomid three days after your final injection. If your cycle concludes with anabolic steroids with large ester bases, you should start HCG ten days after your final injection and then start Clomid once therapy with HCG concludes.

If your cycle finishes with anabolic steroids which have small ester bases, you should start HCG three days after your final injection and then start Clomid once therapy with HCG concludes.

Buy Clomid, Availability and Legality

This drug is available by prescription only, all over the globe. However, there are those who obtain Clomid illegally, via the black market. Clomid is typically not too expensive and it’s also quite simple to find. However, if you want to purchase it legally, you will need to get a prescription for it. You may not need a prescription if you purchase Clomid from a RCL (research chemical lab). Lots of RCLs are out there which offer SERMs, as well as a host of other drugs which anabolic steroid users want, including peptides and aromatase inhibitors. If you buy these from a manufacturer which offers steroids (not a RCL), you’ll be in contravention of the law.

You may notice that Clomid is available online. In general, it’s safer to get it from a RCL, rather than a steroid supplier. Both sell products like this online. Quality from a RCL may be higher. Look into the reputation of a supplier as carefully as you can before placing an order and also keep the letter of the law in mind. Beware of counterfeit Clomid from steroid suppliers. It is out there. If you want a prescription for Clomid, discuss low testosterone with your doctor. Lots of people have low testosterone and it is often possible to get a prescription for Clomid for treatment of low testosterone.

Clomid is a great SERM. It helps to protect against gynecomastia and other side effects from anabolic steroids. People argue about whether it’s better than Nolvadex. Most anabolic steroid users experiment with both and see which one works best for them.

Clomid Chemical Information:

ClomidClomiphene Citrate (AKA Clomid)
Chemical Name: 2-(4-(2-chloro-1,2-diphenylethenyl)phenoxy)-N,N-diethyl-ethanamine
Molecular Weight: 
406 g/mol or 598.10 g/mol (citrate salt)
Original Manufacturer:
Half Life: 
5 – 7 days (some reports as long as 14 days)
Detection Time: 
2 months
Anabolic Rating: 
N/A    Androgenic Rating: N/A