Winstrol is the third most popular and widely used anabolic steroid of all time, with the first being Dianabol (Methandrostenolone) and the second being Deca Durabolin (Nandrolone Decanoate). Winstrol was developed in 1959 and initially manufactured and released onto the prescription drug market by Winthrop Laboratories in the United Kingdom. In 1961, however, Sterling in the United States obtained the patent for the manufacture and sale of Winstrol in 1961 and began manufacturing and selling it on the American prescription drug market in 1962. Although Winstrol is known more popularly as an oral anabolic steroid, its injectable counterpart is commonly referred to as Winstrol Depot. It is named as such because it is designed to be injected deep into muscle tissue where it forms what is known at the site as a depot where the hormone is gradually released from this site. All injectable anabolic steroids are actually properly referred to as depots (whether they are oil-based or water-based does not matter), as the term ‘depot’ is a medical term. Depots can be solid, oil, or water based. Hence, if an anabolic steroid or a drug is followed by the word ‘depot’, it means that it is indeed an injectable variant of the drug.
Winstrol’s major popularity lies in its oral format, although the injectable is fairly popular as well. The reason as to why many individuals opt for the oral Winstrol instead of Winstrol Depot is because there is no difference chemically, structurally, or pharmacologically between the two. Therefore many individuals reason that if there is no difference between them, that they might as well opt for the more convenient route of administration, which tends to be ingestion orally. However, Winstrol Depot does offer a couple of small advantages that the oral format does not. First of all, when Winstrol is ingested orally, it must make a mandatory first pass through the liver (something that must occur with any and all eaten and ingested substances through the oral route). It is through this that the oral version of Winstrol exhibits a greater measure of liver toxicity than Winstrol Depot does. Because Winstrol Depot does not require a first pass through the liver, the potential impact of liver toxicity is greatly diminished (although it is not completely eliminated). Winstrol Depot also exhibits a longer half-life of 24 hours in comparison to the oral variant, which expresses a half-life of 9 hours. This would require less frequent administrations of Winstrol Depot (this will be expanded upon in greater detail shortly).
Of course, because Winstrol is chemically identical whether it is in its oral format or not, Winstrol Depot can indeed be ingested orally (drunken by the user) with the same effect as the ingestion of oral Winstrol tablets. Winstrol Depot is characterised by the fact that it is a water-based injectable suspension. A suspension is a heterogenous mixture that contains solid particles within a liquid, and in order for proper even dispersion prior to administration it must be well shaken. Suspensions can be either an injectable or oral product that is usually water-based (but can also be based in any other types of liquid), with the active ingredient in the form of solid micro crystals. In the case of Winstrol Depot, Winstrol itself is contained in micro crystals that must be shaken prior to injection. Winstrol Depot is generally regarded by many athletes and bodybuilders as being a very painful injectable product due to the fact that it is water based and that the hormone is contained within micro crystals that necessitate larger needle gauges to effectively inject it. Not only is the injection itself reportedly painful, but the following hours and days come with a great deal of post-injection pain (PIP) at the injection site.
Winstrol Depot is commonly found in 50mg/ml preparations as both pharmaceutical grade format as well as underground lab (UGL) product. Preparations containing concentrations greater than 50mg/ml are almost never seen, due to the sheer fact that 50mg/ml is regarded as quite painful and discomforting as it is. However, oil-based solutions of depot are becoming more popular, although it should be noted that these are all underground lab products and that an actual oil-based Winstrol Depot of pharmaceutical origin is yet to be confirmed. Winstrol itself is known to be chemically very difficult to suspend in an oil-based solution, hence why it began as a water based suspension product (and is still the most common form of Winstrol Depot available). Underground laboratories, however, have discovered different recipes of solvents and co-solvents to be able to successfully manufacture Winstrol Depot as an oil-based solution. Through this, higher dosed Winstrol Depot products have been seen (such as 100mg/ml instead of the traditional 50mg/ml). Once again, these products are exclusively of UGL origin (at this time, anyhow).
What Is Winstrol Depot and Why Is It So Popular?
Winstrol Depot’s popularity, as previously mentioned, tends to fall short in comparison to its oral counterpart for the reasons previously outlined. Winstrol is what is known as a Dihydrotestosterone derivative (DHT derivative), belonging to the family of DHT derivatives. Other anabolic steroids within this family include Anadrol (Oxymetholone), Anavar (Oxandrolone), Masteron (Drostanolone), and several others. Anabolic steroids derived from DHT, such as Winstrol, carry with them similar properties and features as the parent hormone (in this case, the parent hormone is Dihydrotestosterone). Winstrol, therefore, is unable to convert into Estrogen (aromatization) at any dose. Its chemical modifications also grant it a very strong anabolic strength. In comparison to Testosterone, Winstrol exhibits 3.2 times the anabolic strength (Testosterone’s anabolic rating is 100 while Winstrol’s anabolic rating is 320). While its anabolic strength is considerably larger than Testosterone, its androgenic strength has been significantly reduced to a rating of 30 (while Testosterone’s androgenic rating is 100).
For a greater in-depth and detailed explanation of why Winstrol possesses these characteristics and what its chemical modifications are, please see the general Winstrol profile. Because Winstrol does not provide any water retention or Estrogen related fat retention/gain, it has become a very popular anabolic steroid for athletes looking to maintain weight and speed without the bulky unwanted water weight. It is therefore a very popular anabolic steroid among athletes in sports such as sprinting, track and field, boxing, and other similar sports where sheer mass and large weight gain is not desired.
How Does Winstrol Depot Work and How Is It Best Used?
Winstrol Depot is quite the versatile anabolic steroid, capable of assisting bulking and mass cycles as equally as cutting cycles. The majority of bodybuilders and athletes tend to utilise Winstrol Depot in cutting and lean mass cycles where raw lean muscle growth is desired without the unsightly and unwanted water retention that tends to bring with it a soft puffy look to the physique. Winstrol Depot is also reported by many athletes and bodybuilders to bring about an accelerated effect on fat loss and leanness. It is commonly revered for its capability to enhance the definition of the physique, bringing out the ‘hard’ and ‘3D’ look to the muscles. As such, it is a particular favourite for pre-contest bodybuilders in the weeks leading up to a competition show.
Because Winstrol Depot avoids the first pass through the liver, it can be run for longer periods of time than its oral counterpart. The oral variant of Winstrol, like all oral C17-alpha alkylated anabolic steroids, is recommended for use no greater than 6 – 8 week periods. Because Winstrol Depot avoids initial direct exposure to the liver, it can be run longer in the range of 10 weeks. However, it should still be understood that because both the oral and injectable variants are 100% identical, Winstrol Depot is also C17-alpha alkylated and will still express a degree of liver toxicity (although lesser than the oral variant) and is one of the only injectable compounds to do so.
Winstrol Depot Side Effects
Side effects that are a little more exclusive to Winstrol Depot have much to do with the uncomfortable and highly irritating injections (resulting almost exclusively from the suspension format). It is not uncommon to have very sore injection sites in the hours and days following administration, and to have a significant loss of range of motion of that muscle due to the pain. Often times, bodybuilders will even have to shift and schedule workouts around their Winstrol Depot injections, as the muscles injected might be too sore and tender to train soon afterwards. Winstrol itself carries with it comes significant side effects as well, most particularly the significant negative impacts on cholesterol levels in the body. Winstrol is notorious for reducing HDL (good cholesterol) levels and increasing LDL (bad cholesterol) levels in the body, which can contribute to increased risk for cardiovascular disease if left negatively altered for extended periods of time. Proper supplementation with cardiovascular supportive nutrients and compounds are highly advised. Being that Winstrol Depot is also C17AA modified, it does exhibit potential liver toxicity, although less so than its oral counterpart. Regardless, it is highly advised to include proven effective liver support compounds (such as TUDCA and/or NAC) during a cycle of Winstrol Depot.